KE547: Chemical Biology
Study Board of Science
Teaching language: English
EKA: N530040102
Assessment: Second examiner: None
Grading: Pass/Fail
Offered in: Odense
Offered in: Summer school (autumn)
Level: Bachelor
STADS ID (UVA): N530040101
ECTS value: 5
Date of Approval: 15-03-2021
Duration: 1 semester
Version: Approved - active
Comment
The course is part of 'Summer School' and is also for foreign students, held in week 32-33.
The course has limited entry. The following criterias are taken into consideration when seats are assigned.
- Students with the most ECTS from their BSc.
- Other studentswith the most ECTS (enrolled in a programme in the subject area of Natural Sciences
The academic enviroments at The faculty of Science manages the prioritisation and at waiting list is established and will then be made aware from the faculty. The waiting list will not be transferred to the following year.
It is important to turn up for the first day of the course or notify the lecturer, as there is a waiting list.
Entry requirements
Students enrolled in bachelor’s or master's programme in Chemistry, Pharmacy, Medicinal chemistry or Biochemistry and molecular biology (BMB).
Academic preconditions
Academic preconditions. Students taking the course are expected to:
- Have basic knowledge of organic molecules, biomolecules and organic reactions.
- Have knowledge of the central dogma of biology
- Be able to use molecular structure to understand properties of molecules.
Participant limit
Course introduction
The aim of the course is to enable the student to understand the underlying biology based on its chemical building blocks and their interactions, which is important in regard to designing better medicines that improve the quality of human life.
Students will learn about the chemical structures and properties of the three main classes of biomolecules – nucleic acids, proteins and lipids – and learn how each of them can play a role in therapeutics, diagnostics or biotechnology. Through lectures, tutorials and laboratory exercises, the course will provide a comprehensive approach to design, synthesis and analysis of natural and unnatural function of important classes of biomolecules.
Expected learning outcome
The learning objective of the course is that the student demonstrates the ability to:
- recognize natural and modified nucleic acids, their secondary structures and possible applications in nanotechnology and gene therapy
- understand the link between protein structure and function
- synthesise peptides and examine them as substrates for biomedically important enzymes
- learn how to immobilize enzymes into solid particles for better applications
- get hands-on experience to encapsulate enzymes into alginate gel for their reuse
- learn about the structure and physico-chemical properties of amphiphiles and their self-assembly into lipid bilayer membranes
- design amphiphilic synthetic biopolymers that can be embedded into lipid membranes
- prepare synthetic lipid membrane nanoparticles – liposomes – and to functionalize them with amphiphilic synthetic DNA or peptides
- perform solid-phase DNA and peptide synthesis
Content
The following main topics are contained in the course:
- DNA / RNA
- Peptides / Proteins
- Nanobiotechnology - Engineering of biological membranes
- Biocatalysis
Literature
Examination regulations
Exam element a)
Timing
August
Tests
Portfolio
EKA
N530040102
Assessment
Second examiner: None
Grading
Pass/Fail
Identification
Full name and SDU username
Language
Normally, the same as teaching language
Examination aids
Allowed
ECTS value
5
Additional information
The Portfolio consist of a) active participation in lectures and other activities and b) Poster presentation. During the poster presentation group of students are evaluated simultaneously.
The form of the reexamination is a report about the experimental work, to be prepared in September month.
The form of the reexamination is a report about the experimental work, to be prepared in September month.
Indicative number of lessons
Teaching Method
The teaching method is based on three phase model.
- Intro phase: 15 hours
- Skills training phase: 35 hours, thereof tutorials: 14 hours and laboratory exercises: 21 hours
Activities during the study phase:
- Solution of assignments in order to discuss these in the exercise sections.
- Solving the project assignments
- Self study of various parts of the course material.
- Reflection upon the intro and training sections.
Teacher responsible
Additional teachers
| Name | Department | City | |
|---|---|---|---|
| Changzhu Wu | wu@sdu.dk | Kemi og Farmaci | |
| Chenguang Lou | chenguang@sdu.dk | Kemi og Farmaci |