BB524: Toxicology B
Study Board of Science
Teaching language: Danish or English depending on the teacher, but English if international students are enrolled
EKA: N100041112, N100041102
Assessment: Second examiner: None, Second examiner: External
Grading: Pass/Fail, 7-point grading scale
Offered in: Odense
Offered in: Spring
Level: Bachelor
STADS ID (UVA): N100041101
ECTS value: 5
Date of Approval: 30-10-2019
Duration: 1 semester
Version: Archive
Comment
Entry requirements
Academic preconditions
Students taking the course are expected to:
- Have knowledge of basic chemistry, molecular biological concepts and biochemical processes
- Have a knowledge of basic toxicological concepts
- Be able to use basic laboratory equipment and perform simple concentration and dilution calculations.
- Basic knowledge of toxicology at the level of BB544: Toxicology A or BB526: Elementary ecotoxicology expected.
Course introduction
The aim of the course is to enable the student to understand the
toxicological data on substances through a thorough knowledge of the
mechanisms of toxicity and the body's defense mechanisms against toxic
effects. This is important in terms of understanding the mechanisms of
side effects and toxic reactions to pharmaceuticals, as well as for the
understanding of food-drug, drug-drug and drug-pollutant interactions.
This knowledge is necessary for pharmacists to advise in pharmacies as
well as for pharmacists and biologists aiming to work in the
pharmaceutical industry and environmental regulation.
toxicological data on substances through a thorough knowledge of the
mechanisms of toxicity and the body's defense mechanisms against toxic
effects. This is important in terms of understanding the mechanisms of
side effects and toxic reactions to pharmaceuticals, as well as for the
understanding of food-drug, drug-drug and drug-pollutant interactions.
This knowledge is necessary for pharmacists to advise in pharmacies as
well as for pharmacists and biologists aiming to work in the
pharmaceutical industry and environmental regulation.
The
course builds on the knowledge acquired in the course Toxicology A (BB544) for pharmacists and biologists and provide a
scientific basis for studying the topics Mechanistic Toxicology
(pharmacists) and Molecular Toxicology (biologists) that is located on
the Master's program.
course builds on the knowledge acquired in the course Toxicology A (BB544) for pharmacists and biologists and provide a
scientific basis for studying the topics Mechanistic Toxicology
(pharmacists) and Molecular Toxicology (biologists) that is located on
the Master's program.
In relation to the education's competency profile, the course explicitly focuses on:
- Provide competence to enter into professional collaboration and structure own learning
- Provide skills in structuring and conducting experimental studies, critically relating to biological theories as well as formulating, assessing and solving biological issues.
- Provide knowledge and reflexive understanding of the scientific theory of biology, of experimental methods and their safety, of current research topics and of their use in the discussion of biological issues.
Expected learning outcome
The learning objective of the course is that the student demonstrates the ability to:
- Explain how nuclear receptors are part of key metabolic and transport processes as well as their role in toxicity
- Describe the impact on hormone systems of pollutants and pharmaceutika
- Explain the molecular mechanisms behind toxicity of selected groups of substances.
- Explain the mechanisms behind the combination effects of substances
- Explain the factors that impede the use of results from animal studies for predicting toxicity in humans
- Explain the sources of pharmaceuticals in nature and effects on wildlife.
- Perform and report quantitative biochemical laboratory tests
- use toxicological data on substances
- read and understand scientific litterature (review papers)
Content
The following main topics are contained in the course:
- Nuclear Receptor-mediated toxicity
- Effects of endocrine disrupters on human reproduction
- Molecular mechanisms underlying the toxicity of metals and natural toxins from plants and fungi
- Sources of species differences in toxicity
- Effects of pharmaceutika on the environment
Literature
Examination regulations
Prerequisites for participating in the exam element a)
Timing
Spring
Tests
Active participation in laboratory exercises
EKA
N100041112
Assessment
Second examiner: None
Grading
Pass/Fail
Identification
Student Identification Card
Language
Normally, the same as teaching language
Examination aids
To be announced during the course
ECTS value
0
Additional information
The prerequisite examination is a prerequisite for participation in exam element a)
Exam element a)
Timing
June
Prerequisites
| Type | Prerequisite name | Prerequisite course |
|---|---|---|
| Examination part | Prerequisites for participating in the exam element a) | N100041101, BB524: Toxicology B |
Tests
Written exam
EKA
N100041102
Assessment
Second examiner: External
Grading
7-point grading scale
Identification
Student Identification Card
Language
Normally, the same as teaching language
Examination aids
A closer description of the exam rules will be posted under 'Course Information' on Blackboard
ECTS value
5
Additional information
The examination form for re-examination may be different from the exam form at the regular exam.
Indicative number of lessons
Teaching Method
The teaching will consist of short introductory lectures on the subjects, which then will be worked out in detail in the form of dialogue through questions. There is thus no special lectures or tutorials. All hours are a mix of lectures, assignments in small groups and shared dialogue on the responses. The laboratory work is closely linked to the theory from the course about nuclear receptor-mediated toxicity and hormon disrupting chemicals. The laboratory part ends with a oral presentation of the laboratory exercises, in order to ensure that the theoretical, academic level has been reached.
Teacher responsible
Additional teachers
| Name | Department | City | |
|---|---|---|---|
| Henrik Holbech | hol@biology.sdu.dk | Biologisk Institut | |
| Katrine Hulgard | khulgard@biology.sdu.dk | Biologisk Institut |