BMB538: Cellular Identity
The Study Board for Science
Teaching language: Danish or English depending on the teacher
EKA: N200030102, N200030112
Assessment: Second examiner: Internal, Second examiner: None
Grading: Pass/Fail
Offered in: Odense
Offered in: Autumn
Level: Bachelor
STADS ID (UVA): N200030101
ECTS value: 5
Date of Approval: 12-04-2023
Duration: 1 semester
Version: Archive
Entry requirements
Enrolment in the Biochemistry and Molecular Biology Bachelor study programme and attendance of BMB544.
Academic preconditions
Students taking the course are expected to meet the specified requirements for the study programme as well as BMB544, which must be attended in parallel.
Course introduction
The aim of the course is to give the student a fundamental understanding of the molecular principles of cellular identity, diversity, and plasticity. The course will introduce technologies from biochemistry and molecular biology used to characterize, visualize, and screen for cellular identity. These will include genomics, proteomics, and luminescence-based strategies. We will focus on select cell types residing in mammalian tissues such as the liver, muscle, and adipose tissue as well as their molecular characterization.
The course will introduce recent, research-based literature, which will help the student to critically engage with research-based environments encountered the future.
In relation to the competence profile of the degree it is the explicit focus of the course to:
- Give competence to describe and employ fundamental concepts within biochemistry and molecular biology
- Give skills individually and in collaboration with fellow students to acquire specialized knowledge in topics related to modern biochemistry and molecular biology and to employ this knowledge in written assignments and reports.
- Provide fundamental knowledge and understanding of cellular identity and diversity as well as modern technologies in biochemistry and molecular biology
Expected learning outcome
The learning objectives of the course is that the student demonstrates the ability to:
- Understand the fundamental principles of cellular identity
- Understand internal and external factors having impact on cellular identity in living organisms
- Account for the central concepts; differentiation, trans-differentiation, as well as cellular plasticity
- Provide examples of shifts in cellular identity seen in development, aging, and disease
- State the most important functions of central cellular organelles
- State central epigenetic principles with known importance to cellular differentiation
- Account for the molecular mechanisms underlying writing and reading of the epigenetic code
- Account for the principles of functional genomic analysis
- Account for the principles of functional proteome analysis
- Account for the principles of luminescence-based techniques for investigation of cellular function and identity
- Account for the principles of functional, cell-based screens
Content
The following main topics are contained in the course:
- Evolution and multi cellularity
- Cellular architecture, structure, and basic functions
- Cellular differentiation and specialization
- Cellular plasticity, dedifferentiation, and transdifferentiation
- Introduction to ‘omics’ for investigation of cellular identity
- Introduction to functional genomics
- Introduction to functional proteomics
- Introduction to luminescence-based methods
- Introduction to functional, cell-based screens
- Introduction to experimental planning
- Literature search for written assignment
Literature
Examination regulations
Exam element b)
Timing
January
Tests
Written exam
EKA
N200030102
Assessment
Second examiner: Internal
Grading
Pass/Fail
Identification
Student Identification Card - Name
Language
Normally, the same as teaching language
Duration
3 hours
Examination aids
All common aids are allowed e.g. books, notes, computer programmes which do not use internet etc.
Internet is not allowed during the exam. However, you may visit the course site in itslearning to open system "DE-Digital Exam". If you wish to use course materials from itslearning, you must download the materials to your computer the day before the exam. During the exam you cannot be sure that all course materials is accessible in itslearning.
ECTS value
3
Additional information
The reexam will be changed to an oral exam, if 9 or fewer students are enrolled. The reexam is without aids and preparation. Duration: 20 minutes including votation.
Exam element a)
Timing
Autumn
Tests
Written group assignment with oral presentation
EKA
N200030112
Assessment
Second examiner: None
Grading
Pass/Fail
Identification
Full name and SDU username
Language
Normally, the same as teaching language
Examination aids
Allowed, a closer description of the exam rules will be posted in itslearning.
ECTS value
2
Indicative number of lessons
Teaching Method
At the faculty of science, teaching is organized after the three-phase model ie. intro, training and study phase.
- • Intro phase (lectures, class lessons) 20 hours
- Training phase: 20 hours, including 20 hours tutorials
- Studyphase: 85 hours
Activities during the study phase:
- Reading of course syllable
- Completion of theoretical assignments
- Written assignment in groups
There is a close connection between the preparation of the assignment and the training phase, there will be ample opportunity for guidance in task preparation as part of the training phase.
Teacher responsible
| Name | Department | |
|---|---|---|
| Kim Ravnskjær | ravnskjaer@bmb.sdu.dk | Institut for Biokemi og Molekylær Biologi |
Additional teachers
| Name | Department | City | |
|---|---|---|---|
| Lars Grøntved | larsgr@bmb.sdu.dk | Funktionelle Genomiske Studier og Metabolisme |
Timetable
Administrative Unit
Team at Registration
Offered in
Recommended course of study
Transition rules
Transitional arrangements describe how a course replaces another course when changes are made to the course of study.
If a transitional arrangement has been made for a course, it will be stated in the list.
See transitional arrangements for all courses at the Faculty of Science.