BMB538: Cellular Identity
Study Board of Science
Teaching language: Danish, but English if international students are enrolled
EKA: N200030112, N200030102
Assessment: Second examiner: None, Second examiner
Grading: Pass/Fail
Offered in: Odense
Offered in: Autumn
Level: Bachelor
STADS ID (UVA): N200030101
ECTS value: 5
Date of Approval: 25-03-2019
Duration: 1 semester
Version: Archive
Comment
Entry requirements
Enrolment in the Biochemistry and Molecular Biology Bachelor study programme and attendance of the Molecular Biology Module of FF503.
Academic preconditions
Students taking the course are expected to meet the specified requirements for the study programme as well as the Molecular Biology Module of FF503, which must be attended in parallel.
Course introduction
The aim of the course is to give the student a fundamental understanding of the molecular principles of cellular identity, diversity, and plasticity. The course will introduce technologies from biochemistry and molecular biology used to characterize, visualize, and screen for cellular identity. These will include genomics, proteomics, and luminescence-based strategies. We will focus on select cell types residing in mammalian tissues such as the liver, muscle, and adipose tissue as well as their molecular characterization.
The course will introduce recent, research-based literature, which will help the student to critically engage with research-based environments encountered the future.
In relation to the competence profile of the degree it is the explicit focus of the course to:
- Give competence to describe and employ fundamental concepts within biochemistry and molecular biology
- Give skills individually and in collaboration with fellow students to acquire specialized knowledge in topics related to modern biochemistry and molecular biology and to employ this knowledge in written assignments and reports.
- Provide fundamental knowledge and understanding of cellular identity and diversity as well as modern technologies in biochemistry and molecular biology
Expected learning outcome
The learning objectives of the course is that the student demonstrates the ability to:
- Understand the fundamental principles of cellular identity
- Understand internal and external factors having impact on cellular identity in living organisms
- Account for the central concepts; differentiation, trans-differentiation, as well as cellular plasticity
- Provide examples of shifts in cellular identity seen in development, aging, and disease
- State the most important functions of central cellular organelles
- State central epigenetic principles with known importance to cellular differentiation
- Account for the molecular mechanisms underlying writing and reading of the epigenetic code
- Account for the principles of functional genomic analysis
- Account for the principles of functional proteome analysis
- Account for the principles of luminescence-based techniques for investigation of cellular function and identity
- Account for the principles of functional, cell-based screens
Content
The following main topics are contained in the course:
- Evolution and multi cellularity
- Cellular architecture, structure, and basic functions
- Cellular differentiation and specialization
- Cellular plasticity, dedifferentiation, and transdifferentiation
- Introduction to ‘omics’ for investigation of cellular identity
- Introduction to functional genomics
- Introduction to functional proteomics
- Introduction to luminescence-based methods
- Introduction to functional, cell-based screens
- Introduction to experimental planning
- Literature search for written assignment
Literature
Examination regulations
Exam element a)
Timing
Autumn
Tests
Written group assignment with oral presentation
EKA
N200030112
Assessment
Second examiner: None
Grading
Pass/Fail
Identification
Full name and SDU username
Language
Normally, the same as teaching language
Examination aids
Allowed, a closer description of the exam rules will be posted in itslearning.
ECTS value
2
Additional information
The examination form for re-examination may be different from the exam form at the regular exam.
Exam element b)
Timing
January
Tests
Written exam
EKA
N200030102
Assessment
Second examiner
Grading
Pass/Fail
Identification
Student Identification Card
Language
Normally, the same as teaching language
Duration
3 hours
Examination aids
Allowed, a closer description of the exam rules will be posted in itslearning.
ECTS value
3
Additional information
The examination form for re-examination may be different from the exam form at the regular exam.
Indicative number of lessons
Teaching Method
At the faculty of science, teaching is organized after the three-phase model ie. intro, training and study phase.
Activities during the study phase:
- Reading of course syllable
- Completion of theoretical assignments
- Written assignment in groups
There is a close connection between the preparation of the assignment and the training phase, there will be ample opportunity for guidance in task preparation as part of the training phase.
Teacher responsible
| Name | Department | |
|---|---|---|
| Kim Ravnskjær | ravnskjaer@bmb.sdu.dk | Institut for Biokemi og Molekylær Biologi |
Additional teachers
| Name | Department | City | |
|---|---|---|---|
| Lars Grøntved | larsgr@bmb.sdu.dk | Institut for Biokemi og Molekylær Biologi, ATLAS - Center for Functional Genomics and Tissue Plasticity |