FA808: Advanced drug formulation
Study Board Pharmacy
Teaching language: Danish or English depending on the teacher
EKA: N570000102, N570000112
Assessment: Second examiner: None
Grading: 7-point grading scale, Pass/Fail
Offered in: Odense
Offered in: Autumn
Level: Master
STADS ID (UVA): N570000101
ECTS value: 5
Date of Approval: 16-05-2020
Duration: 1 semester
Version: Archive
Comment
3855501 (former UVA) is identical with this course description.
The course cannot be followed by students in clinical profile if they are enrolled in "Evidence-based drug use and biostatics", as this will overlap.
Limited number of seats:
The course has a limited number of seats (36). If more than 36 students have registered timely, FKF will give priority to the students registered (method 2), and a waiting list may be established. Pharmacy students enrolled at the technological profile will be given preference.
Entry requirements
The courses Drug formulation and production (FA502, FA503 and FA504) at bachelor pharmacy must be passed.
Academic preconditions
Students taking the course are expected to:
- have participated the teaching in bachelor education in pharmacy (especially the courses in drug formulation and production, FA502, FA503 and FA504, and the course Drug Transport and Drug Delivery Systems at the master education in pharmacy.
- have practical experiences of laboratory work and fundamental laboratory safety rules.
- have knowledge about relevant databases.
Participant limit
Course introduction
The aim of the course is to deepen theoretical and experimental aspects of modern advanced drug formulation to optimize the therapeutic efficiency of drug therapy. The course will provide the students and deeper understanding of advanced formulation strategies with respect on both formulation development and marketed medicines.
The course thus contributes providing the students with competences which are needed for a pharmacist to perform in the area of drug formulation development as well as consulting clinical professionals on medicines.
In relation to the competence profile, the explicit focus of the course is to:
- provide knowledge and understanding of advanced drug formulation for at optimize the therapeutic efficiency of drug therapy, especially focusing on improvement bioavailability after oral administration, controlled drug release and drug targeting.
- train skills in manufacturing and characterization of advanced dosage forms (such as nano- and microparticulate dispersions, self-emulsifying formulations, solid dispersions), in searching and evaluation of scientific literature and in discussing professional issues.
- evaluate and use scientific literature.
- provide competences in critical and problem-oriented assessment and discussion of advanced dosage forms with respect on both formulation development and marketed medicines.
Expected learning outcome
The learning objectives of the course is that the student demonstrates the ability:
- to apply relevant physicochemical terms and principles in drug formulation
- to explain relevant biopharmaceutical and therapeutic questions in relation to drug formulation
- to use relevant databases for searching the scientific literature and professional information
- to discuss marketed advanced medicines and advanced formulation principles in drug development
- to analyze and discuss experimental results
- to present theoretical contexts and experimental results in both oral and written form
Content
The following main topics are included in the course:
- parenteral depot formulations (microparticles, in-situ forming implants)
- nanoparticulate drug formulations for intravenous administration (liposomes, fat emulsions, nanoparticles) incl. drug targeting principles
- formulation principles of oral medicines with improved bioavailability of critical drug compounds (self-emulsifying formulations, solid dispersions and nanocrystals)
- formulation and manufacturing principles of selected above-mentioned drug formulations
- selected analytical methods to characterize the above-mentioned drug formulations (such as microscopy, UV/Vis spectroscopy, particle size analysis, X-ray diffraction, thermal analysis)
Literature
P.J. Sinko: Martin’s Physical Pharmacy and Pharma-ceutical Sciences, Wolters Kluwer.
Y. Perrie, T. Rades: Pharmaceutics – Drug Delivery and Targeting, Pharmaceutical Press.
Further literature will be provided via E-Learn.
See Blackboard for syllabus lists and additional literature references.
Examination regulations
Exam element a)
Timing
January
Prerequisites
| Type | Prerequisite name | Prerequisite course |
|---|---|---|
| Examination part | Prerequisites for participating in the exam a) | N570000101, FA808: Advanced drug formulation |
Tests
Report and oral presentation, overall assessment.
EKA
N570000102
Assessment
Second examiner: None
Grading
7-point grading scale
Identification
Full name and SDU username
Language
Normally, the same as teaching language
Examination aids
To be announced during the course
ECTS value
5
Additional information
The examination form for re-examination may be different from the exam form at the regular exam.
Prerequisites for participating in the exam a)
Timing
Autumn
Tests
Participation in compulsory examinations and laboratory exercises.
EKA
N570000112
Assessment
Second examiner: None
Grading
Pass/Fail
Identification
Full name and SDU username
Language
Normally, the same as teaching language
Examination aids
To be announced during the course
ECTS value
0
Additional information
The examination form for re-examination may be different from the exam form at the regular exam.
The prerequisite examination is a prerequisite for participation in exam element a)
The prerequisite examination is a prerequisite for participation in exam element a)
Indicative number of lessons
Teaching Method
At the faculty of science, teaching is organized after the three-phase model ie. intro, training and study phase.
- intro phase (lectures) - number of hours 4
- training phase - number of hours 42, 24 h seminar and 18 h laboratory
The intro phase consists of lectures providing a short introduction into the central topics of the course.
The training phase provides competences within the central topics of the course. During the seminars, the students will work in small groups on a selected topic (theoretical project) and results of the laboratory exercises will be discussed. I the lab exercises, selected experiments and tests within the central topics of course will be performed.
During the study phase, the students will independently work with the literature to obtain and deepen the central topics of the course. Moreover, the students will recapitulate the tasks from the training phase (writing of reports, work on the theoretical projects) and prepare the final presentation of the theoretical project.
Activities during the study phase:
- self-study and after work of topics from the lectures
- literature search and evaluation
- analysis of results from the laboratory exercises
- preparation of a presentation of a selected topic
- report writing