BMB809: Advanced Molecular Biology
Study Board of Science
Teaching language: Danish, but English if international students are enrolled
EKA: N210010112, N210010102
Assessment: Second examiner: None, Second examiner: External
Grading: 7-point grading scale
Offered in: Odense
Offered in: Spring
Level: Master
STADS ID (UVA): N210010101
ECTS value: 10
Date of Approval: 23-10-2018
Duration: 1 semester
Version: Archive
Comment
01010501(former UVA) is identical with this course description.
The course is co read with BMB508: Advanced Molecular Biology (10 ECTS)
The course is co read with BMB508: Advanced Molecular Biology (10 ECTS)
Entry requirements
Academic preconditions
Course introduction
The course is a continuation of the course ”Fundamental Molekylær
Biologi” and the aim is to provide a coherent understanding of the
transmission and exchange of biological information as well as
differences in molecular-biological processes in prokaryotic and
eukaryotic organisms. Selected examples comprising a diverse range of
organisms, including man, will be used to illustrate cellular functions
and the development of organisms.
Biologi” and the aim is to provide a coherent understanding of the
transmission and exchange of biological information as well as
differences in molecular-biological processes in prokaryotic and
eukaryotic organisms. Selected examples comprising a diverse range of
organisms, including man, will be used to illustrate cellular functions
and the development of organisms.
Expected learning outcome
Having completed the course the student is expected to be able to:
- describe the general structure of eukaryotic genes and the transcriptional control of gene expression in eukaryotic cells
- describe how posttranscriptional processes, including nuclear-cytoplasmic transport, are regulated and control gene expression
- describe how different classes of membrane bound receptors are activated and how signals are transduced from the cell membrane to nucleus
- describe how different cell types are specified, how the early development is regulated in different eukaryotic organisms, and how terminal differentiation of cells is controlled
- describe how anti-apoptotic and apoptotic signals regulate survival and apoptosis
- describe how the cell cycle is regulated in eukaryotic cells
- describe how proto-oncogenes, oncogenes and tumour suppressors control the normal cell cycle and development, and how changes in these genes contribute to the development of cancer
- describe how carcinogenic substances can result in formation of cancer cells
- analyse results from research articles and on this basis formulate new hypotheses
- Critically evaluate experimental, molecular-biological methods
Content
The course will cover the following topics:
- Regulation of transcription in eukaryotic organisms.
- Posttranscriptional regulation, RNA modification, processing, splicing, catalytic RNA and nuclear-cytoplasmic transport
- Translation of mRNA in eukaryotic organisms.
- Control of gene activity via cellular signalling.
- Cellular signal transduction and integration of cellular signalling in the control of gene activity and development.
- Control of the cell cycle in eukaryotic organisms
- Development, differentiation and programmed cell death in eukaryotic organisms.
- Cancer at the molecular level, oncogenes, tumour suppressors, DNA damage and repair, signal transduction, hormones and receptors.
- Selected examples of molecular genetics of diseases.
New
technology in molecular biology, including recombinant technology and
DNA analyses by polymerase chain reaction (PCR), will be tested during
laboratory exercises.
Literature
Examination regulations
Exam element a)
Timing
Spring
Tests
Group report on laboratory exercises
EKA
N210010112
Assessment
Second examiner: None
Grading
7-point grading scale
Identification
Full name and SDU username
Language
Normally, the same as teaching language
Examination aids
To be announced during the course
ECTS value
3
Additional information
Re-exam may have a different format.
Exam element b)
Timing
June
Tests
Written examination
EKA
N210010102
Assessment
Second examiner: External
Grading
7-point grading scale
Identification
Student Identification Card
Language
Normally, the same as teaching language
Duration
2 hours
Examination aids
Not allowed, a closer description of the exam rules will be posted under Course Information on Blackboard.
ECTS value
7
Additional information
The examination form for re-examination may be different from the exam form at the regular exam.
Indicative number of lessons
Teaching Method
The course will consist of lectures (40 hours) supplemented by tutorial
lessons (24 hours), laboratory exercises (15 hours) and study groups
going through articles (four hours). Communication between teachers and
students regarding lecture notes, assignments etc. will take place via
the university’s e-learning system.