FA507: Instrumental pharmaceutical analysis

• give the competence to critically evaluate and use different analytical methods to solve quantitative and qualitative issues according to official monographs (e.g. Ph.Eur.) and guidelines (ICH, GLP) as well as relevant scientific literature.
• acquire skills to perform and optimize analytical methods, to perform structural, qualitative and quantitative analysis (calibration, standards) to calculate validation parameters (including precision, accuracy, selectivity, detection limit, quantification limit, separation and column parameters) and use statistical methods in data processing to report experimental results in easy-to-understand language.
• give knowledge on key concepts and principles of the analytical process (validation, statistical analysis methods), spectroscopic methods incl. structural analysis (UV / Vis, fluorescence, IR, NMR, MS), chromatographic separation methods (HPLC, TLC, GC, SEC, electrophoresis) and coupling of separation methods with common detection.

• be able to critically evaluate and use analytical instrumental methods to solve qualitative and quantitative analytical pharmaceutical issues and to take into account official monographs (Ph. Eur.), guidelines (ICH, GLP) and scientific literature (competencies).
• be able to perform and optimize analytical methods, use spectroscopic methods for qualitative analysis (structural analysis), perform quantitative determination (calibration, standards), calculate validation parameters including precision, accuracy, selectivity, detection limit, quantification limit, separation and column parameters, using statistical methods test results in easily understandable, accurate and correct language (skills).
• know key concepts and principles of the analytical processes (validation, statistical analysis methods), spectroscopic methods incl. for structural analysis (UV / Vis, fluorescence, IR, NMR, MS), chromatographic separation methods (HPLC, TLC, GC, SEC, electrophoresis) and coupling of separation methods with common detection methods (knowledge).

• Fundamentals of philosophy of science and scientific methods
• Instrumental analysis in the pharmaceutical sciences and GMP
• The analytical process (GLP, systematic and random errors, qualification and validation, statistical methods, guidelines such as GLP and ICH, sample preparation),
• Quantitative and qualitative analysis in the pharmaceutical science
• Spectroscopic methods (UV / Vis, fluorescence, IR, NMR, MS), principles, instrumentation and application in the pharmaceutical science
• Chromatographic methods (HPLC, TLC, GC, SEC, electrophoresis) as well as their common detection methods, principles, instrumentation and application in the pharmaceutical science
• Structural analysis by IR, NMR and MS
• Quantitative analysis (calibration, internal and external standard, selectivity)

At the faculty of science, teaching is organized after the three-phase model ie. intro, training and study phase.
In order to enable students to achieve the learning objectives for the course, the teaching is organised in such a way that there are 90 lectures, class lessons, etc. on a semester. These teaching activities are reflected in an estimated allocation of the workload of an average student as follows:

•  Intro phase (lectures) - 28 hours
• Training phase: 62 hours, including 34 hours tutorials, 24 hours laboratory, Demonstrations study: 3-5 hours.
  In addition, excursion 10 hours (one working day).

• Self-study of the textbook and other relevant literature especially with respect to work with theory from the lectures and to prepare for the seminars and laboratory exercises.
• Exercises, data analysis and report writing
• Continuous work and repetition of course materials and topics.