KE835: Heterocyclic chemistry

• If there are fewer than 12 students enrolled, the course may. be held with another teaching form.
• The course is co-read with the corresponding bachelor course KE553 (former KE526)
• If you plan to attend both Heterocyclic chemistry (KE553/KE835) and Advanced organic synthesis (KE518/KE814) in your complete study program, we recommend that you first attend KE553/KE835 or that you attend the two courses simultaneously.
• The course is primarily held in the first half of the spring semester

Students who attend the course are expected to: 

• be familiar with physical and organic chemistry including the structure and reactions of organic molecules as well as the concept of pH and thermodynamics.
• have experience with the use of reaction mechanisms

KE505: Organic chemistry (10 ECTS), KE521: Chemistry of the elements (5 ECTS) or KE528: Introductory Inorganic Chemistry (5 ECTS) and KE537: Microscopic and macroscopic physical chemistry are required to be known.
Similar courses in organic and physical chemistry, such as organic chemistry and physical chemistry on the engineer degree programme in chemistry and biotechnology, can also provide the academic prerequisites.

• the basic knowledge formation of chemistry and experimental methods within organic chemistry,
  
• current topics within modern international chemistry research,
• knowledge of topics within the chemistry research that is conducted by the staff at the Department of Physics, Chemistry and Pharmacy
• the ability to understand and reflect on theories, methods and practices within the field of chemistry,
• the ability to acquire knowledge in an efficient and independent manner and the ability to apply this knowledge in a reflective way, as well as skills to apply methods for investigating specific chemical phenomena theoretically and / or experimentally, as well as competencies to take responsibility for one's own academic development. 

The learning objectives of the course is that the student demonstrates the ability to:

• provide names for simple aliphatic and aromatic heterocycles
• use reaction mechanisms to predict the formation of selected heterocyclic compounds
• explain and account for the reactivity of selected heterocyclic compounds
• explain and discuss the applications of selected heterocyclic compounds inmedicinal chemistry and supramolecular chemistry

• General nomenclature of heterocyclic compounds
• Synthesis and chemical properties of heterocyclic compounds including pyrroles, furans, thiophenes, various five-membered heterocycles with several heteroatoms, pyridines, diazines and annullated heterocycles
• Use of reactions mechanisms to account for the formation of heterocyclic compounds
• Examples of applications of heterocycles in for example medicinal chemistry and supramolecular chemistry

• John A. Joule and Keith Mills: Heterocyclic Chemistry, 5th Edition
• Other material will be communicated via itslearning.

At the faculty of science, teaching is organized after the three-phase model ie. intro, training and study phase. These teaching activities are reflected in an estimated allocation of the workload of an average student as follows:

• Intro phase (lectures) - 30 hours
• Training phase: 12 hours

In the study phase, students are expected to work on their own with the textbook and examples herein. It also includes preparation of written exercises as a key element in the study phase. The students will independently search for and read research papers. The students are also expected to use part of the study phase to pick up on the content of training phase and to reserve a small amount of time for repetition for the oral exam.

Activities during the studyphase:

• Self-study of the textbook
• Written hand-in exercises
• Search in scientific literature
• Repetition for the exam