KE828: Medicinal chemistry B
Study Board of Science
Teaching language: Danish or English depending on the teacher, but English if international students are enrolled
EKA: N540040102, N540040112
Assessment: Second examiner: External, Second examiner: None
Grading: 7-point grading scale, Pass/Fail
Offered in: Odense
Offered in: Spring
Level: Master
STADS ID (UVA): N540040101
ECTS value: 5
Date of Approval: 31-10-2022
Duration: 1 semester
Version: Archive
Comment
Entry requirements
Academic preconditions
Students taking the course are expected to:
- Have knowledge of basic biochemistry
- Have knowledge of fundamental organic chemistry
- Have knowledge of fundamental medicinal chemistry
Course introduction
The aim of the course is to enable the student to understand the effect of physico-chemical properties of a drug on the pharmacokinetic properties and how to optimize these, which is important in regard to development of new drugs with good ADMET properties.
The course builds on the knowledge acquired in the courses medicinal chemistry A (KE511/FA506), organic chemistry (KE505) and basic biochemistry (BMB530), and gives an academic basis for performing a master thesis within the field of medicinal chemistry.
In relation to the competence profile of the degree it is the explicit focus of the course to:
- Give the competence to take responsibility for own professional development
- Give the competence to development solution models both individually and in teams across study background (chemistry/medicinal chemistry/pharmacy)
- Give skills to communicate and critically analyse research results and research-based knowledge
- Give knowledge and understanding of important elements in drug design and optimization in the pre-clinical phase of drug development
- Give knowledge and understanding of experimental methods used within medicinal chemistry research
Expected learning outcome
The learning objectives of the course are that the student demonstrates the ability to:
- Explain the effect of physico-chemical properties on drugs ADMET properties.
- Explain and discuss different optimization strategies of physico-chemical properties including the use of physico-chemical decriptors.
- Explain target-ligand interactions and methods for optimization of these.
- Discuss medicinal chemistry articles containing ADMET data.
Content
The following main topics are contained in the course:
- Physicochemical properties and descriptors (pKa, lipophilicity, solubility, Fsp3, LE, LLE etc.)
- ADMET (permeability, metabolic stability, plasma stability, CYP inhibition, hERG blocking, toxicity, pharmacokinetics, blood-brain barrier)
- Optimization strategies (e.g. the use of fluorine and deuterium)
- Target-ligand interactions
- Fragment based drug design
- Modeling in medicinal chemistry (pharmacophores, homology models, docking, in silico screening)
- Case studies
Literature
Examination regulations
Exam element a)
Timing
June
Prerequisites
Type | Prerequisite name | Prerequisite course |
---|---|---|
Examination part | Prerequisites for participating in the exam a) | N540040101, KE828: Medicinal chemistry B |
Tests
Oral examination
EKA
N540040102
Assessment
Second examiner: External
Grading
7-point grading scale
Identification
Student Identification Card
Language
Normally, the same as teaching language
Duration
25 minutes
Examination aids
Article, presentation (for instance PowerPoint), and computer for the presentation.
ECTS value
5
Additional information
Oral examination without preparation time. Article for the exam will be handed out no later than two weeks before the exam.
Prerequisites for participating in the exam a)
Timing
Spring
Tests
4 electronic tests
EKA
N540040112
Assessment
Second examiner: None
Grading
Pass/Fail
Identification
Full name and SDU username
Language
Normally, the same as teaching language
Examination aids
To be announced during the course.
ECTS value
0
Additional information
The prerequisite examination is a prerequisite for participation in exam element a)
Indicative number of lessons
Teaching Method
At the faculty of science, teaching is organized after the three-phase model ie. intro, training and study phase.
- Intro phase - 26 hours
- Training phase: 16 hours, including 16 hours tutorials
Activities during the study phase:
- Self-study of course book and articles
- Solve exercises
- E-tests
- Preparation of student presentations
- Revision for the exam
Teacher responsible
Timetable
Administrative Unit
Team at Educational Law & Registration
Offered in
Recommended course of study
Profile | Education | Semester | Offer period |
---|---|---|---|
MSC major in Medicinal Chemistry - registration 1 September 2020, 2021 og 2022 | | Odense | 2 | E22 |
Transition rules
Transitional arrangements describe how a course replaces another course when changes are made to the course of study.
If a transitional arrangement has been made for a course, it will be stated in the list.
See transitional arrangements for all courses at the Faculty of Science.