KE811: Advanced NMR spectroscopy
If there are fewer than 12 students enrolled, the course may. be held with another teaching form.
Bachelor’s degree in Chemistry, Pharmaceutical Sciences, Nanobioscience or Chemical Engineering, or minor in Chemistry.
Students taking the course are expected to:
- be able to apply NMR spectroscopy as an analytical tool
- know the theoretical basis for NMR spectroscopy and quantum chemistry
- possess fundamental math skills
- KE826: Spectroscopy (5 ECTS) or similar should be attended before the course.
The course builds on the knowledge acquired in a course on analytical spectroscopy, e.g. KE504, in basic math and quantum chemistry courses and besides this knowledge of the basics of NMR theory, e.g. KE826.
The course will show various applications of NMR spectroscopy and hence afford students with knowledge of detailed state-of-art applications of NMR.
In relation to the competence profile of the degree it is the explicit focus of the course to give students the ability to apply NMR spectroscopy in structural characterisation in a broad sense.
Expected learning outcome
At the end of the course the students should be able to:
common solid-state and solution NMR experiments (HNMR, CNMR, DEPT,
INEPT, HETCOR, HSQC, HMQC, COSY, DQCOSY, INADEQUATE, NOESY,
NOE-difference, CP, MAS) and discuss their application to structure
- solve the Bloch-equations and employ these to explain NMR experiments by means of the vector model.
scalar-, dipolar- and quadrupolar interactions and their influence on
the position, intensity, splitting and width of the lines in an NMR
spectrum as well as relaxation times and NOE.
- apply the notion of chemical shift and employ chemical shifts to determine the stereo structure of a molecule.
- calculate chemical shifts in order to differentiate between possible structures.
intensities in HNMR and CNMR and perspectivate factors that influence
those (number of nuclei, NOE, relaxation times, exchange)
- analyze spin-spin couplings and use first order spin-spin analysis in order to determine the stereo structure of a molecule.
- analyze second order effects and employ the concepts chemical and magnetic equivalence.
- Horst Friebolin: Basic One- and Two- Dimensional NMR Spectroscopy, Wiley-VCH. Noters
See Blackboard for syllabus lists and additional literature references.