KE811: Advanced NMR spectroscopy

Study Board of Science

Teaching language: Danish, but English if international students are enrolled
EKA: N540029102
Censorship: Second examiner: None
Grading: Pass/Fail
Offered in: Odense
Offered in: Spring
Level: Master's level course approved as PhD course

STADS ID (UVA): N540029101
ECTS value: 5

Date of Approval: 24-10-2018


Duration: 1 semester

Version: Approved - active

Comment

10003501(former UVA) is identical with this course description. 
If there are fewer than 12 students enrolled, the course may. be held with another teaching form. 

Entry requirements

Bachelor’s degree in Chemistry, Pharmaceutical Sciences, Nanobioscience or Chemical Engineering, or minor in Chemistry.

Academic preconditions

Students taking the course are expected to:

  • be able to apply NMR spectroscopy as an analytical tool
  • know the theoretical basis for NMR spectroscopy and quantum chemistry
  • possess fundamental math skills
  • KE826: Spectroscopy (5 ECTS) or similar should be attended before the course.

Course introduction

The aim of the course is to give students a theoretical understanding of NMR spectroscopy and to show applications within NMR spectroscopy.

The course builds on the knowledge acquired in a course on analytical spectroscopy, e.g. KE504, in basic math and quantum chemistry courses and besides this knowledge of the basics of NMR theory, e.g. KE826.

The course will show various applications of NMR spectroscopy and hence afford students with knowledge of detailed state-of-art applications of NMR.

In relation to the competence profile of the degree it is the explicit focus of the course to give students the ability to apply NMR spectroscopy in structural characterisation in a broad sense.

Expected learning outcome

At the end of the course the students should be able to:

  • perspectivate
    common solid-state and solution NMR experiments (HNMR, CNMR, DEPT,
    INEPT, HETCOR, HSQC, HMQC, COSY, DQCOSY, INADEQUATE, NOESY,
    NOE-difference, CP, MAS) and discuss their application to structure
    determination.
  • solve the Bloch-equations and employ these to explain NMR experiments by means of the vector model.
  • discuss
    scalar-, dipolar- and quadrupolar interactions and their influence on
    the position, intensity, splitting and width of the lines in an NMR
    spectrum as well as relaxation times and NOE.
  • apply the notion of chemical shift and employ chemical shifts to determine the stereo structure of a molecule. 
  • calculate chemical shifts in order to differentiate between possible structures.
  • use
    intensities in HNMR and CNMR and perspectivate factors that influence
    those (number of nuclei, NOE, relaxation times, exchange)
  • analyze spin-spin couplings and use first order spin-spin analysis in order to determine the stereo structure of a molecule.
  • analyze second order effects and employ the concepts chemical and magnetic equivalence.

Content

The following main topics are contained in the course:
NMR Spectrocopy

Literature

  • Horst Friebolin: Basic One- and Two- Dimensional NMR Spectroscopy, Wiley-VCH. Noters

See Blackboard for syllabus lists and additional literature references.

Examination regulations

Exam element a)

Timing

Spring

Tests

Reports

EKA

N540029102

Censorship

Second examiner: None

Grading

Pass/Fail

Identification

Full name and SDU username

Language

Normally, the same as teaching language

Examination aids

To be announced during the course

ECTS value

5

Additional information

The examination form for re-examination may be different from the exam form at the regular exam.

Indicative number of lessons

50 hours per semester

Teaching Method

  • Working with reports

Teacher responsible

Name E-mail Department
Paul C. Stein pcs@sdu.dk

Additional teachers

Name E-mail Department City
Michael Petersen mip@sdu.dk
Ulla Gro Nielsen ugn@sdu.dk

Timetable

Administrative Unit

Fysik, kemi og Farmaci

Team at Registration & Legality

NAT

Recommended course of study

Profile Programme Semester Period