KE811: Advanced NMR spectroscopy
The Study Board for Science
Teaching language: Danish, but English if international students are enrolled
EKA: N540029102
Assessment: Second examiner: None
Grading: Pass/Fail
Offered in: Odense
Offered in: Spring
Level: Master's level course approved as PhD course
STADS ID (UVA): N540029101
ECTS value: 5
Date of Approval: 24-10-2018
Duration: 1 semester
Version: Archive
Comment
Entry requirements
Bachelor’s degree in Chemistry, Pharmaceutical Sciences, Nanobioscience or Chemical Engineering, or minor in Chemistry.
Academic preconditions
Students taking the course are expected to:
- be able to apply NMR spectroscopy as an analytical tool
- know the theoretical basis for NMR spectroscopy and quantum chemistry
- possess fundamental math skills
- KE826 Spectroscopy should be attended before the course.
Course introduction
The aim of the course is to give students a theoretical understanding of NMR spectroscopy and to show applications within NMR spectroscopy.
The course builds on the knowledge acquired in a course on analytical spectroscopy, e.g. KE504, in basic math and quantum chemistry courses and besides this knowledge of the basics of NMR theory, e.g. KE826.
The course will show various applications of NMR spectroscopy and hence afford students with knowledge of detailed state-of-art applications of NMR.
In relation to the competence profile of the degree it is the explicit focus of the course to give students the ability to apply NMR spectroscopy in structural characterisation in a broad sense.
The course builds on the knowledge acquired in a course on analytical spectroscopy, e.g. KE504, in basic math and quantum chemistry courses and besides this knowledge of the basics of NMR theory, e.g. KE826.
The course will show various applications of NMR spectroscopy and hence afford students with knowledge of detailed state-of-art applications of NMR.
In relation to the competence profile of the degree it is the explicit focus of the course to give students the ability to apply NMR spectroscopy in structural characterisation in a broad sense.
Expected learning outcome
At the end of the course the students should be able to:
- perspectivate
common solid-state and solution NMR experiments (HNMR, CNMR, DEPT,
INEPT, HETCOR, HSQC, HMQC, COSY, DQCOSY, INADEQUATE, NOESY,
NOE-difference, CP, MAS) and discuss their application to structure
determination. - solve the Bloch-equations and employ these to explain NMR experiments by means of the vector model.
- discuss
scalar-, dipolar- and quadrupolar interactions and their influence on
the position, intensity, splitting and width of the lines in an NMR
spectrum as well as relaxation times and NOE. - apply the notion of chemical shift and employ chemical shifts to determine the stereo structure of a molecule.
- calculate chemical shifts in order to differentiate between possible structures.
- use
intensities in HNMR and CNMR and perspectivate factors that influence
those (number of nuclei, NOE, relaxation times, exchange) - analyze spin-spin couplings and use first order spin-spin analysis in order to determine the stereo structure of a molecule.
- analyze second order effects and employ the concepts chemical and magnetic equivalence.
Content
Literature
- Horst Friebolin: Basic One- and Two- Dimensional NMR Spectroscopy, Wiley-VCH. Noters
See Blackboard for syllabus lists and additional literature references.
Examination regulations
Exam element a)
Timing
Spring
Tests
Reports
EKA
N540029102
Assessment
Second examiner: None
Grading
Pass/Fail
Identification
Full name and SDU username
Language
Normally, the same as teaching language
Examination aids
To be announced during the course
ECTS value
5
Additional information
The examination form for re-examination may be different from the exam form at the regular exam.