BB807: Molecular Toxicology

Study Board of Science

Teaching language: Danish, but English if international students are enrolled
EKA: N110007112, N110007102
Censorship: Second examiner: None, Second examiner: Internal
Grading: Pass/Fail, 7-point grading scale
Offered in: Odense
Offered in: Autumn
Level: Master's level course approved as PhD course

STADS ID (UVA): N110007101
ECTS value: 5

Date of Approval: 25-04-2019


Duration: 1 semester

Version: Approved - active

Comment

04014801 (former UVA) is identical with this course description. 

Entry requirements

A Bachelor’s degree in life sciences.

Academic preconditions

Students taking the course are expected to:

  • Have knowledge of basic toxicology, chemistry and biochemistry
  • Be able to use basic chemical and biochemical knowledge to recognise chemical and cellular structures

Course introduction

The aim of the course is to enable the student to understand, at the molecular level, the mechanisms behind toxicity and the relations between the cellular defence systems against toxicity. This is important in regard to reading and understanding advanced original literature on toxicological subjects.

The course builds on the knowledge acquired in the course BB524: Elementary Ecotoxicology and gives an academic basis for studying toxicology.

In relation to the competence profile of the degree it is the explicit focus of the course to:

  • Give the competence to understand advanced toxicological original research papers
  • Give skills to generalise about the fate of chemicals from their chemical structure
  • Give practical skills in planning experiments  from original literature
  • Give knowledge and understanding of molecular mechanisms of toxicity and defence systems against toxicity

Expected learning outcome

The learning objectives of the course is that the student demonstrates the ability to:
  • Describe the biochemical pathways leading to the bioactivation of selected chemicals
  • Predict the metabolic fate of compounds from their chemical structure
  • Describe the molecular mechanisms behind the deleterious effects of selected chemicals on membranes, proteins and DNA
  • Discuss impact and timing of toxic manifestations in the cell
  • Describe the molecular mechanisms behind the deleterious effects of selected chemicals on energy production and metabolism
  • Discuss toxic effects on the organ level as a consequence of molecular events
  • Describe the cellular defence systems against oxidative stress, metals and lipophilic compounds
  • Discuss the interrelation between defence systems and the consequences of suppression of sub-systems

Content

The following main topics are contained in the course:
  • Cellular transport of xenobiotics; selective accumulation and organ specific toxicity.
  • Bioactivation of compounds by the Phase-I and Phase-II systems
  • Oxidative stress, free radicals and lipid peroxidation of cell membranes
  • Covalent binding of chemicals to biological macromolecules
  • Nuclear receptor mediated toxicity

Literature

See Blackboard for syllabus lists and additional literature references.

Examination regulations

Prerequisites for participating in the exam a)

Timing

Fall

Tests

Lab work

EKA

N110007112

Censorship

Second examiner: None

Grading

Pass/Fail

Identification

Full name and SDU username

Language

Normally, the same as teaching language

Examination aids

To be announced during the course

ECTS value

0

Additional information

The examination form for re-examination may be different from the exam form at the regular exam.
Reexamination in the same exam period or immediately thereafter. 

Exam element a)

Timing

January

Prerequisites

Type Prerequisite name Prerequisite course
Examination part Prerequisites for participating in the exam a) N110007101, BB807: Molecular Toxicology

Tests

Written exam

EKA

N110007102

Censorship

Second examiner: Internal

Grading

7-point grading scale

Identification

Student Identification Card

Language

Normally, the same as teaching language

Examination aids

Not allowed, A closer description of the exam rules will be posted under \'Course Information\' on Blackboard.
Dansk

ECTS value

5

Additional information

Reeksamen i samme eksamenstermin eller i umiddelbar forlængelse heraf. The examination form for re-examination may be different from the exam form at the regular exam.

Indicative number of lessons

50 hours per semester

Teaching Method

Activities during the study phase:
Preparation for laboratory work

Teacher responsible

Name E-mail Department
Henrik Holbech hol@biology.sdu.dk Biologisk Institut

Additional teachers

Name E-mail Department City
Johannes Lørup Buch jbuch@biology.sdu.dk Biologisk Institut

Timetable

44
Monday
01-11-2021
Tuesday
02-11-2021
Wednesday
03-11-2021
Thursday
04-11-2021
Friday
05-11-2021
08 - 09
Class f
Forelæsning
Class h1e
Undervisning
09 - 10
Class f
Forelæsning
Class h1e
Undervisning
10 - 11
Class h1e
Undervisning
11 - 12
Class h1e
Undervisning
12 - 13
13 - 14
14 - 15
15 - 16
Show full time table

Administrative Unit

Biologisk Institut

Team at Registration & Legality

NAT

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