KE547: Chemical Biology

Study Board of Science

Teaching language: English
EKA: N530040102
Censorship: Second examiner
Grading: Pass/Fail
Offered in: Odense
Offered in: Summer school (autumn)
Level: Bachelor

STADS ID (UVA): N530040101
ECTS value: 5

Date of Approval: 15-03-2021


Duration: 1 semester

Version: Archive

Comment

The course is part of 'Summer School' and is also for foreign students, held in week 32-33. 

Entry requirements

Students enrolled in bachelor’s or master's programme in Chemistry, Pharmacy, Medicinal chemistry or Biochemistry and molecular biology (BMB).

Academic preconditions

Academic preconditions. Students taking the course are expected to:

  • Have basic knowledge of organic molecules, biomolecules and organic reactions.
  • Have knowledge of the central dogma of biology
  • Be able to use molecular structure to understand properties of molecules.

Participant limit

40

Course introduction

The aim of the course is to enable the student to understand the underlying biology based on its chemical building blocks and their interactions, which is important in regard to designing better medicines that improve the quality of human life.

Students will learn about the chemical structures and properties of the three main classes of biomolecules – nucleic acids, proteins and lipids – and learn how each of them can play a role in therapeutics, diagnostics or biotechnology. Through lectures, tutorials and laboratory exercises, the course will provide a comprehensive approach to design, synthesis and analysis of natural and unnatural function of important classes of biomolecules.

Expected learning outcome

The learning objective of the course is that the student demonstrates the ability to:
  • recognize natural and modified nucleic acids, their secondary structures and possible applications in nanotechnology and gene therapy
  • understand the link between protein structure and function
  • synthesise peptides and examine them as substrates for biomedically important enzymes
  • learn how to immobilize enzymes into solid particles for better applications
  • get hands-on experience to encapsulate enzymes into alginate gel for their reuse
  • learn about the structure and physico-chemical properties of amphiphiles and their self-assembly into lipid bilayer membranes
  • design amphiphilic synthetic biopolymers that can be embedded into lipid membranes
  • prepare synthetic lipid membrane nanoparticles – liposomes – and to functionalize them with amphiphilic synthetic DNA or peptides
  • perform solid-phase DNA and peptide synthesis

Content

The following main topics are contained in the course:
  • DNA / RNA
  • Peptides / Proteins
  • Nanobiotechnology - Engineering of biological membranes
  • Biocatalysis

Literature

See Itslearning for syllabus lists and additional literature references.

Examination regulations

Exam element a)

Timing

August

Tests

Portfolio

EKA

N530040102

Censorship

Second examiner

Grading

Pass/Fail

Identification

Student Identification Card

Language

Normally, the same as teaching language

Examination aids

Allowed. 

ECTS value

5

Additional information

The Portfolio consist of a) active participation in lectures and other activities and b) Poster presentation. During the poster presentation group of students are evaluated simultaneously.

The examination form for re-examination may be different from the exam form at the regular exam.

Indicative number of lessons

50 hours per semester

Teaching Method

The teaching method is based on three phase model.
  • Intro phase: 15 hours
  • Skills training phase: 35 hours, thereof tutorials: 14 hours and laboratory exercises: 21 hours
Activities during the study phase:
  • Solution of assignments in order to discuss these in the exercise sections.
  • Solving the project assignments
  • Self study of various parts of the course material.
  • Reflection upon the intro and training sections.

Teacher responsible

Name E-mail Department
Jasmin Mecinovic mecinovic@sdu.dk Institut for Fysik, Kemi og Farmaci

Additional teachers

Name E-mail Department City
Changzhu Wu wu@sdu.dk Institut for Fysik, Kemi og Farmaci, Danish Institute for Advanced Study
Chenguang Lou chenguang@sdu.dk Institut for Fysik, Kemi og Farmaci
Philipp M. G. Löffler pmgl@sdu.dk Institut for Fysik, Kemi og Farmaci

Timetable

25
Monday
20-06-2022
Tuesday
21-06-2022
Wednesday
22-06-2022
Thursday
23-06-2022
Friday
24-06-2022
08 - 09
09 - 10
10 - 11
11 - 12
12 - 13
13 - 14
14 - 15
15 - 16
Show full time table

Administrative Unit

Fysik, kemi og Farmaci

Team at Educational Law & Registration

NAT

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