KE547: Chemical Biology
Academic preconditions. Students taking the course are expected to:
- Have basic knowledge of organic molecules, biomolecules and organic reactions.
- Have knowledge of the central dogma of biology
- Be able to use molecular structure to understand properties of molecules.
Students will learn about the chemical structures and properties of the three main classes of biomolecules – nucleic acids, proteins and lipids – and learn how each of them can play a role in therapeutics, diagnostics or biotechnology. Through lectures, tutorials and laboratory exercises, the course will provide a comprehensive approach to design, synthesis and analysis of natural and unnatural function of important classes of biomolecules.
Expected learning outcome
- recognize natural and modified nucleic acids, their secondary structures and possible applications in nanotechnology and gene therapy
- understand the link between protein structure and function
- synthesise peptides and examine them as substrates for biomedically important enzymes
- learn how to immobilize enzymes into solid particles for better applications
- get hands-on experience to encapsulate enzymes into alginate gel for their reuse
- learn about the structure and physico-chemical properties of amphiphiles and their self-assembly into lipid bilayer membranes
- design amphiphilic synthetic biopolymers that can be embedded into lipid membranes
- prepare synthetic lipid membrane nanoparticles – liposomes – and to functionalize them with amphiphilic synthetic DNA or peptides
- perform solid-phase DNA and peptide synthesis
- DNA / RNA
- Peptides / Proteins
- Nanobiotechnology - Engineering of biological membranes
Exam element a)
The Portfolio consist of a) active participation in lectures and other activities and b) Poster presentation. During the poster presentation group of students are evaluated simultaneously.
The examination form for re-examination may be different from the exam form at the regular exam.
Indicative number of lessons
- Intro phase: 15 hours
- Skills training phase: 35 hours, thereof tutorials: 14 hours and laboratory exercises: 21 hours
- Solution of assignments in order to discuss these in the exercise sections.
- Solving the project assignments
- Self study of various parts of the course material.
- Reflection upon the intro and training sections.
|Changzhu Wuemail@example.com||Institut for Fysik, Kemi og Farmaci, Danish Institute for Advanced Study|
|Chenguang Loufirstname.lastname@example.org||Institut for Fysik, Kemi og Farmaci|
|Philipp M. G. Löffleremail@example.com||Institut for Fysik, Kemi og Farmaci|
|08 - 09|
|09 - 10|
|10 - 11|
|11 - 12|
|12 - 13|
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|14 - 15|
|15 - 16|