BB807: Molecular Toxicology
Study Board of Science
Teaching language: Danish, but English if international students are enrolled
EKA: N110007112, N110007102
Assessment: Second examiner: None, Second examiner: Internal
Grading: Pass/Fail, 7-point grading scale
Offered in: Odense
Offered in: Autumn
Level: Master's level course approved as PhD course
STADS ID (UVA): N110007101
ECTS value: 5
Date of Approval: 25-04-2019
Duration: 1 semester
Version: Archive
Comment
Entry requirements
Academic preconditions
Students taking the course are expected to:
- Have knowledge of basic toxicology, chemistry and biochemistry
- Be able to use basic chemical and biochemical knowledge to recognise chemical and cellular structures
Course introduction
The aim of the course is to enable the student to understand, at the molecular level, the mechanisms behind toxicity and the relations between the cellular defence systems against toxicity. This is important in regard to reading and understanding advanced original literature on toxicological subjects.
The course builds on the knowledge acquired in the course BB524: Elementary Ecotoxicology and gives an academic basis for studying toxicology.
In relation to the competence profile of the degree it is the explicit focus of the course to:
- Give the competence to understand advanced toxicological original research papers
- Give skills to generalise about the fate of chemicals from their chemical structure
- Give practical skills in planning experiments from original literature
- Give knowledge and understanding of molecular mechanisms of toxicity and defence systems against toxicity
Expected learning outcome
The learning objectives of the course is that the student demonstrates the ability to:
- Describe the biochemical pathways leading to the bioactivation of selected chemicals
- Predict the metabolic fate of compounds from their chemical structure
- Describe the molecular mechanisms behind the deleterious effects of selected chemicals on membranes, proteins and DNA
- Discuss impact and timing of toxic manifestations in the cell
- Describe the molecular mechanisms behind the deleterious effects of selected chemicals on energy production and metabolism
- Discuss toxic effects on the organ level as a consequence of molecular events
- Describe the cellular defence systems against oxidative stress, metals and lipophilic compounds
- Discuss the interrelation between defence systems and the consequences of suppression of sub-systems
Content
The following main topics are contained in the course:
- Cellular transport of xenobiotics; selective accumulation and organ specific toxicity.
- Bioactivation of compounds by the Phase-I and Phase-II systems
- Oxidative stress, free radicals and lipid peroxidation of cell membranes
- Covalent binding of chemicals to biological macromolecules
- Nuclear receptor mediated toxicity
Literature
Examination regulations
Prerequisites for participating in the exam a)
Timing
Fall
Tests
Lab work
EKA
N110007112
Assessment
Second examiner: None
Grading
Pass/Fail
Identification
Full name and SDU username
Language
Normally, the same as teaching language
Examination aids
To be announced during the course
ECTS value
0
Additional information
The examination form for re-examination may be different from the exam form at the regular exam.
Reexamination in the same exam period or immediately thereafter.
Reexamination in the same exam period or immediately thereafter.
Exam element a)
Timing
January
Prerequisites
| Type | Prerequisite name | Prerequisite course |
|---|---|---|
| Examination part | Prerequisites for participating in the exam a) | N110007101, BB807: Molecular Toxicology |
Tests
Written exam
EKA
N110007102
Assessment
Second examiner: Internal
Grading
7-point grading scale
Identification
Student Identification Card
Language
Normally, the same as teaching language
Examination aids
Not allowed, A closer description of the exam rules will be posted under \'Course Information\' on Blackboard.
Dansk
ECTS value
5
Additional information
Reeksamen i samme eksamenstermin eller i umiddelbar forlængelse heraf. The examination form for re-examination may be different from the exam form at the regular exam.