BMB536: Metabolic Regulation
Study Board of Science
Teaching language: Danish
EKA: N200027102
Assessment: Second examiner: Internal
Grading: 7-point grading scale
Offered in: Odense
Offered in: Spring
Level: Bachelor
STADS ID (UVA): N200027101
ECTS value: 7.5
Date of Approval: 02-10-2019
Duration: 1 semester
Version: Archive
Comment
Entry requirements
Academic preconditions
Students taking the course are expected to:
- Have knowledge of fundamental biochemistry and basic organic chemistry.
- Be able to apply basic biochemistry and organic chemistry to discuss how biochemical processes are integrated and regulated.
Course introduction
The aim of the course is to enable the student to understand metabolic pathways in mammalian cells and their regulation at a molecular level. Participants will gain insights into signal transduction pathways incl. hormones, growth factors, receptors, kinases, calcium and transcription factors. This is important in regard to the understanding of biochemical processes, which are key elements in understanding human physiology under normal and pathological conditions.
The course builds on knowledge acquired in courses in Fundamental Biochemistry like BMB530 or BMB532 which is assumed known, and provide a scientific basis to further study topics in physiology, pathophysiology and experimental work under the BSC and thesis projects that are part of the degree.
In relation to the competence profile of the degree it is the explicit focus of the course to:
- Give competences in discussing and analyzing regulation of metabolism and biochemical processes at the molecular level.
- Give skills to discuss regulation of metabolism in mammals and physiological mechanisms.
- Give knowledge and understanding of how;
- 1) biochemical processes are regulated at the molecular level
- 2) how these are interconnected,
- 3) how metabolic processes are integrated with each other between the various bodies.
Expected learning outcome
The learning objective of the course is that the student demonstrates the ability to:
- describe metabolites, enzymes, co-enzymes in glycogen and fatty acid metabolism and its regulation.
- explain
the formation and function of lipoproteins like chylomicrons, VLDL, HDL
and LDL, and describe their respective roles in triglyceride /
cholesterol homeostasis. - explain how the vesicular transport takes place in eukaryotic cells.
- describe how high levels of cholesterol can lead to the development of cardiovascular diseases.
- explain
the synthesis of phospholipids and triglycerides and how the synthesis
of phospholipids is closely associated with amino acid metabolism. - explain how glucogenic and ketogenic amino acids are converted and how the amino groups may be disposed in the urea cycle.
- explain how amino acids are synthesized from intermediates in glycolysis and TCA cycle.
- describe how synthesis of branched chain amino acids and glutamine synthesis is regulated.
- on the basis of own experiments explain the glucose-fatty acid cycle.
- explain
the effect of the hormones insulin, glucagon, norepinephrine and
epinephrine on the metabolic pathways in the brain, muscles, liver and
adipose tissue. - describe the mechanisms underlying the hormonal effect on blood levels of glucose, fatty acids and ketone bodies.
- explain
the metabolic adaptations that occur as a result of food intake,
fasting and diabetes (type 1 and 2) as well as muscle work. - describe
the structure and function of 7TM receptors, G proteins and signaling
pathways that lead to the formation of secondary "messengers" such as
Ca2+, IP3 and cAMP, and explain how the activity of these signaling
pathways and the level of these messengers can be regulated. - describe
the structure and function of tyrosine kinase receptors, including
insulin receptor, and explain how the PI3 kinase signaling and MAPK
signaling can be activated by insulin.
Content
The following main topics are contained in the course:
- Regulation of glycolysis/gluconeogenesis/TCA
- Lipid absorption, transport and lipoproteins
- Membrane trafficking
- Fatty acid degradation
- Fatty acid synthesis
- Complex lipid synthesis
- Amino acid metabolism
- Signal transduction
- Regulation of metabolism incl. glucose-fatty acid cycle
- Integration of metabolism
- Ca2+ signalling
- Metabolic diseases
Literature
- David L. Nelson and Michael M. Cox: Lehninger Principles of Biochemistry, 6. Udgave.
- K. Frayn: Metabolic Regulation, a human perspective, 3. Udgave.
- Øvelsesvejledning.
See Blackboard for syllabus lists and additional literature references.
Examination regulations
Exam element a)
Timing
Spring
Tests
Port folio exam
EKA
N200027102
Assessment
Second examiner: Internal
Grading
7-point grading scale
Identification
Full name and SDU username
Language
Normally, the same as teaching language
Examination aids
To be announced during the course
ECTS value
7.5
Additional information
The course is evaluated by a portfolio exam consisting of 4 electronic exams with aids (BlackBoard), which will be held during the course and a written exam in June at SDU. The 4 electronic exams are opened at a specified time and are kept open for approximately 3 days. The exam at SDU in June is without aids covering the various topics of the course. Each of the first four exam can only be taken once.
Grades are given based on final number of accumulated points. Distribution of exams and points could be as follows: Mid March: 10%, Primo April: 10%, end of April: 10%, mid May: 10%, mid June: 60%. Internal marking by teacher. When all exams have been completed a final grade is given, based on the combined number of points obtained. Grades given according til the 7-mark scale. (01013502). Participation in the exam in june is obligatory to obtain the grade 02 or higher.
As a starting point the reexamination will physically take place at on campus in Odense and will count 100%. Points obtained during the 4 part-examinations and the final examination in june will expire and will not be valid at the day of re-examination. The mode od reexamination may differ from the ordinary exam.
Indicative number of lessons
Teaching Method
At the faculty of science, teaching is organized after the three-phase model ie. intro, training and study phase.
Activities during the studyphase
- Preparation for lectures, tutorials and exercises
- Studying for part exams