BMB541: Principles of the Development of Pharmaceuticals

Comment

Entry requirements

this course can only be selected if:

It is a mandatory part of your degree program.
It is specifically recommended as an elective ECTS course in the suggested study plan.
It is part of a defined transition for a course you have not yet completed.

Academic preconditions

The course runs in close dialogue with the concurrent course BMB549 and builds on the fundamental molecular and cell biological knowledge acquired there.

Course introduction

The aim of the course is to enable students to understand and engage with the principles of pharmaceutical development, including the use of modern biotechnology in the treatment of human diseases, as well as to comprehend the role of a biomedical scientist. Furthermore, the course helps students contextualize later courses with a higher level of theoretical abstraction within a broader framework.

Expected learning outcome

To achieve the course's objectives, the learning goals for the course are that the student demonstrates the ability to:

Understand the overarching principles of developing new drugs up to approval for clinical use.
Gain knowledge of the process involved in identifying new drugs.
Understand the general process of how biological drugs are produced.
Comprehend the design and evaluation of a clinical study.
Understand the molecular basis of selected diseases.
Understand the principles for identifying development strategies for drugs, based on knowledge of the molecular basis of diseases.
Gain knowledge of the effects of selected drugs on the organism.

Content

The course includes the following main academic areas:

The history of drug development
Processes and phases in pharmaceutical research
Drug interaction with targets or receptors
Pharmacokinetics and pharmacodynamics
Toxicological testing of drugs
Processes and phases in drug development
Clinical studies: design and statistical evaluation
Production of biological drugs
Molecular understanding of diseases as a prerequisite for drug development
Information retrieval related to task solving
Molecular basis for selected diseases
Antibodies as drugs

Literature

Wiley Blackwell: Drugs; From Discovery to Approval, af Rick Ng, 3rd edition.
Kopier af uddrag fra bøger og tidsskrifter, disse udleveres under kurset.

See itslearning for syllabus lists and additional literature references.

Examination regulations

Exam element a)

Timing

Autumn

Tests

New

EKA

N200020112

Assessment

Second examiner: None

Grading

Pass/Fail

Identification

Full name and SDU username

Language

Normally, the same as teaching language

Examination aids

To be announced during the course

ECTS value

2.5

Exam element b)

Timing

January

Tests

Written exam

EKA

N200020102

Assessment

Second examiner: Internal

Grading

7-point grading scale

Identification

Student Identification Card - Name

Language

Normally, the same as teaching language

Duration

2 hours

Examination aids

The exam is with limited aids. Only the following aids are allowed:

Built-in standard calculators in Windows/macOS/Linux.
Maple, Mathematica, Mathcad, MATLAB, GeoGebra Apps, R (including R-Studio), CAS TI-Nspire, MS Excel, and LibreOffice Calc are allowed. WordMat is permitted but not recommended. Use of WordMat is at your own risk, and no support will be provided for breakdowns or other errors caused by the program.

Internet is not allowed. However, you may access the course page in itslearning to open system "DE–Digital Exam" and complete any tests within the system.

ECTS value

2.5

Additional information

The exam is conducted as a multiple choice test.

Indicative number of lessons

40 hours per semester

Teaching Method

Planned lessons:

Total number of planned lessons: 40

Hereof:

Common lessons in classroom/auditorium: 22

Team lessons in classroom: 18

Common lessons consist of presentations where students are broadly informed about various aspects of pharmaceutical research, focusing on topics relevant to biomedical students. Additionally, they will receive guidance on skill acquisition and information retrieval.

During team lessons, which include computer simulations and problem-based learning, students work on various assignments, thereby gaining competencies in the central aspects of the course.

Other planned teaching activities:

Students are expected to work independently with the textbook, examples, and exercises therein. They are also expected to spend a significant amount of time working on assignments related to the group sessions and reviewing for the written exam.

Activities include:

Reading the curriculum
Watching videos covering parts of the curriculum
Solving theoretical exercises
Preparing group assignments
Working with computer simulations, e-tests, etc.

Teacher responsible

Name	E-mail	Department
Jonas Heilskov Graversen	jgraversen@health.sdu.dk	Cancer & Inflammationsforskning - Inflammation

Additional teachers

Name	E-mail	Department	City
Peter Zvara	pzvara@health.sdu.dk	Klinisk Institut
Tore B. Stage	tstage@health.sdu.dk	Institut for Sundhedstjenesteforskning

Timetable

Odense

Show full time table

Administrative Unit

Biokemi og Molekylær Biologi

Team at Registration

NAT

Offered in

Odense

Recommended course of study

Profile	Education	Semester	Offer period

Transition rules

Transitional arrangements describe how a course replaces another course when changes are made to the course of study.

If a transitional arrangement has been made for a course, it will be stated in the list.

See transitional arrangements for all courses at the Faculty of Science.