FA506: Medicinal Chemistry A

Entry requirements

None

Academic preconditions

Students taking the course are expected to:

Have good knowledge of KE505 Organic chemistry A
Have knowledge of fundamental cell biology

Course introduction

The aim of the course is to give the student an overview over the central parts of medicinal chemistry, including the mechanism of action of active principles in drugs, and a more detailed insight in selected medicinal chemistry themes and drug classes. The course will enable the student to integrate knowledge from organic chemistry, biology and molecular biology, toxicology, physiology and medicine. Furthermore, the course will train the students in critical reading of scientific literature and in scientific presentation.

Expected learning outcome

The learning objectives of the course is that the student demonstrates the ability to:

Demonstrate a broad overview over medicinal compound classes
Explain and use important terms in medicinal chemistry, including agonism and antagonism, SAR, ADME, pharmacokinetics and pharmacodynamics
Explain the mechanism of action of representative drugs
Provide an overview of important molecular drug targets in the body
Draw the chemical structures of central signaling molecules and drugs
Provide an overview of, recognize and explain types of molecular interactions between the drug and the target
Formulate hypotheses for interactions between a given drug and a target and for how this interaction can be optimized
Provide an overview of and explain absorption, distribution, metabolism and excretion of drugs and formulate hypotheses for how the chemical structure of a given drug can optimized with regard to these factors
Read and understand articles in the medicinal chemistry journals and critically analyze, interpret and explain the reported results.
Analyzed a dataset for a given compound series, form hypotheses for structure-activity relationships and formulate optimization strategies

Content

The following main topics are contained in the course:

Drugs and drug targets in general
Drug-target interactions
Proteins
Enzymes as drug targets
Receptors as drug targets
Pharmacokinetics
Drug discovery and development
Lead identification
Lead optimization – optimizing drug target interaction and pharmacokinetic properties
Antibacterial agents
Nucleic acids as drug targets
Antiviral agents
Anticancer drugs
The cholinergic system
The adrenergic system
Opioid analgesics
Antiulcer agents

Literature

Graham L. Patrick: An Introduction to Medicinal Chemistry, 7th Ed, Oxford, 2023.
See itslearning for syllabus lists and additional literature references.

Examination regulations

Prerequisites for participating in the exam a)

Timing

Autumn

Tests

Group presentation of articles

EKA

N560010112

Assessment

Second examiner: None

Grading

Pass/Fail

Identification

Full name and SDU username

Language

Normally, the same as teaching language

Examination aids

To be announced during the course

ECTS value

Additional information

The prerequisite examination is a prerequisite for participation in exam element a)

Exam element a)

Timing

January

Prerequisites

Type	Prerequisite name	Prerequisite course
Examination part	Prerequisites for participating in the exam a)	N560010101, FA506: Medicinal Chemistry A

Tests

Written exam

EKA

N560010102

Assessment

Second examiner: External

Grading

7-point grading scale

Identification

Student Identification Card - Name

Language

Normally, the same as teaching language

Duration

3 hours

Examination aids

All common aids are allowed e.g. books, notes, computer programmes which do not use internet etc.

Internet is not allowed during the exam. However, you may visit the course site in itslearning to open system "DE-Digital Exam". If you wish to use course materials from itslearning, you must download the materials to your computer the day before the exam. During the exam you cannot be sure that all course materials is accessible in itslearning.

ECTS value

Indicative number of lessons

36 hours per semester

Teaching Method

Planned lessons:

Total number of planned lessons: 36

Hereof:

Common lessons in classroom/auditorium: 20

Team lessons in classroom: 16

The teaching consists of lectures where dialogue between teacher and students is encouraged. Here, a concise introduction to the course topics and the path to competence attainment is given to complement the textbook, lecture presentation slides provided by the teacher and scientific articles, which students are expected to study independently.

In the teaching, competences in the core parts of the course are build and trained. Some of the teaching hours are based on problem solving based on important basic principles of the subject with joint assignments and individual presentations in groups (2-4 students) of scientific articles in the field from recent years. Group discussions of individual student presentations are performed in plenary.

Other planned teaching activities:

Studies of the textbook
Written exercises
Studies of scientific articles
Preparations of article presentations in groups
Repetitions for the exam

Teacher responsible

Name	E-mail	Department
Stefan Vogel	snv@sdu.dk	Kemi og Farmaci

Timetable

Odense

Show full time table

Administrative Unit

Fysik, kemi og Farmaci

Team at Registration

NAT

Offered in

Odense

Recommended course of study

Profile	Education	Semester	Offer period

Transition rules

Transitional arrangements describe how a course replaces another course when changes are made to the course of study.

If a transitional arrangement has been made for a course, it will be stated in the list.

See transitional arrangements for all courses at the Faculty of Science.