FA808: Advanced drug formulation

Study Board Pharmacy

Teaching language: Danish or English depending on the teacher, but English if international students are enrolled
EKA: N570000102, N570000112
Assessment: Second examiner: None
Grading: 7-point grading scale, Pass/Fail
Offered in: Odense
Offered in: Autumn
Level: Master

STADS ID (UVA): N570000101
ECTS value: 5

Date of Approval: 31-03-2023


Duration: 1 semester

Version: Archive

Comment

Limited number of seats: The course has a limited number of seats (24). If more than 24 students have registered timely, FKF will give priority to the students registered (method 2), and a waiting list may be established. Pharmacy students enrolled at the technological profile will be given preference.

Entry requirements

The courses Drug formulation and production (FA511: Drug formulation and production A (7,5 ECTS), FA503: Drug formulation and production B (5 ECTS) and FA504: Drug formulation and production C (5 ECTS)) at bachelor pharmacy must be passed.

The course cannot be followed by students in clinical profile if they are enrolled in "Evidence-based drug use and biostatics", as this will overlap.

Academic preconditions

Students taking the course are expected to:

  • have participated the teaching in bachelor education in pharmacy, and the course Drug Transport and Drug Delivery Systems (5 ECTS) at the master education in pharmacy.
  • have practical experiences of laboratory work and fundamental laboratory safety rules.
  • have knowledge about relevant databases.

Participant limit

24

Course introduction

The aim of the course is to deepen theoretical and experimental aspects of modern advanced drug formulation to optimize the therapeutic efficiency of drug therapy. The course will provide the students and deeper understanding of advanced formulation strategies with respect on both formulation development and marketed medicines.

The course thus contributes providing the students with competences which are needed for a pharmacist to perform in the area of drug formulation development as well as consulting clinical professionals on medicines. 

In relation to the competence profile, the explicit focus of the course is to:
  • provide knowledge and understanding of advanced drug formulation for at optimize the therapeutic efficiency of drug therapy, especially focusing on improvement bioavailability after oral administration, controlled drug release and drug targeting.
  • train skills in manufacturing and characterization of advanced dosage forms (such as nano- and microparticulate dispersions, self-emulsifying formulations, solid dispersions), in searching and evaluation of scientific literature and in discussing professional issues.
  • evaluate and use scientific literature.
  • provide competences in critical and problem-oriented assessment and discussion of advanced dosage forms with respect on both formulation development and marketed medicines.

Expected learning outcome

The learning objective of the course is that the student demonstrates the ability:
  • to apply relevant physicochemical terms and principles in drug formulation
  • to explain relevant biopharmaceutical and therapeutic questions in relation to drug formulation
  • to use relevant databases for searching the scientific literature and professional information
  • to discuss marketed advanced medicines and advanced formulation principles in drug development
  • to analyze and discuss experimental results
  • to present theoretical contexts and experimental results in both oral and written form

Content

The following main topics are included in the course:
  • parenteral depot formulations (microparticles, in-situ forming implants)
  • nanoparticulate drug formulations for intravenous administration (liposomes, fat emulsions, nanoparticles) incl. drug targeting principles
  • formulation principles of oral medicines with improved bioavailability of critical drug compounds (self-emulsifying formulations, solid dispersions and nanocrystals)
  • formulation and manufacturing principles of selected above-mentioned drug formulations
  • selected analytical methods to characterize the above-mentioned drug formulations (such as microscopy, UV/Vis spectroscopy, particle size analysis, X-ray diffraction, thermal analysis)

Literature

Y. Perrie, T. Rades: Pharmaceutics – Drug Delivery and Targeting, Pharmaceutical Press.

Further literature will be provided via E-Learn.
See itslearning for syllabus lists and additional literature references.

Examination regulations

Exam element a)

Timing

January

Prerequisites

Type Prerequisite name Prerequisite course
Examination part Prerequisites for participating in the exam a) N570000101, FA808: Advanced drug formulation

Tests

Report and oral presentation

EKA

N570000102

Assessment

Second examiner: None

Grading

7-point grading scale

Identification

Full name and SDU username

Language

Normally, the same as teaching language

Examination aids

To be announced during the course

ECTS value

5

Additional information

Examination consists of a report and oral presentation, overall assessment.
Reexamination - Oral examination (30 minutes)

Prerequisites for participating in the exam a)

Timing

Autumn

Tests

Participation in compulsory examinations and laboratory exercises.

EKA

N570000112

Assessment

Second examiner: None

Grading

Pass/Fail

Identification

Full name and SDU username

Language

Normally, the same as teaching language

Examination aids

To be announced during the course

ECTS value

0

Additional information

.The prerequisite examination is a prerequisite for participation in exam element a)

Indicative number of lessons

46 hours per semester

Teaching Method

At the faculty of science, teaching is organized after the three-phase model ie. intro, training and study phase.

  • intro phase (lectures) - number of hours 4
  • training phase - number of hours 42, 24 h seminar and 18 h laboratory

The intro phase consists of lectures providing a short introduction into the central topics of the course.
The training phase provides competences within the central topics of the course. During the seminars, the students will work in small groups on a selected topic (theoretical project) and results of the laboratory exercises will be discussed. I the lab exercises, selected experiments and tests within the central topics of course will be performed.
During the study phase, the students will independently work with the literature to obtain and deepen the central topics of the course. Moreover, the students will recapitulate the tasks from the training phase (writing of reports, work on the theoretical projects) and prepare the final presentation of the theoretical project.

Activities during the study phase:
  • self-study and after work of topics from the lectures
  • literature search and evaluation
  • analysis of results from the laboratory exercises
  • preparation of a presentation of a selected topic

Teacher responsible

Name E-mail Department
Judith Kuntsche kuntsche@sdu.dk Kemi og Farmaci

Timetable

Administrative Unit

Fysik, kemi og Farmaci

Team at Educational Law & Registration

NAT

Offered in

Odense

Recommended course of study

Profile Education Semester Offer period

Transition rules

Transitional arrangements describe how a course replaces another course when changes are made to the course of study. 
If a transitional arrangement has been made for a course, it will be stated in the list. 
See transitional arrangements for all courses at the Faculty of Science.