FA808: Advanced drug formulation
Comment
Limited number of seats: The course has a limited number of seats (24). If more than 24 students have registered timely, FKF will give priority to the students registered (method 2), and a waiting list may be established. Pharmacy students enrolled at the technological profile will be given preference.
Entry requirements
The courses Drug formulation and production (FA511: Drug formulation and production A (7,5 ECTS), FA503: Drug formulation and production B (5 ECTS) and FA504: Drug formulation and production C (5 ECTS)) at bachelor pharmacy must be passed.
The course cannot be followed by students in clinical profile if they are enrolled in "Evidence-based drug use and biostatics", as this will overlap.
Academic preconditions
Students taking the course are expected to:
- have participated the teaching in bachelor education in pharmacy, and the course Drug Transport and Drug Delivery Systems (5 ECTS) at the master education in pharmacy.
- have practical experiences of laboratory work and fundamental laboratory safety rules.
- have knowledge about relevant databases.
Participant limit
Course introduction
- provide knowledge and understanding of advanced drug formulation for at optimize the therapeutic efficiency of drug therapy, especially focusing on improvement bioavailability after oral administration, controlled drug release and drug targeting.
- train skills in manufacturing and characterization of advanced dosage forms (such as nano- and microparticulate dispersions, self-emulsifying formulations, solid dispersions), in searching and evaluation of scientific literature and in discussing professional issues.
- evaluate and use scientific literature.
- provide competences in critical and problem-oriented assessment and discussion of advanced dosage forms with respect on both formulation development and marketed medicines.
Expected learning outcome
- to apply relevant physicochemical terms and principles in drug formulation
- to explain relevant biopharmaceutical and therapeutic questions in relation to drug formulation
- to use relevant databases for searching the scientific literature and professional information
- to discuss marketed advanced medicines and advanced formulation principles in drug development
- to analyze and discuss experimental results
- to present theoretical contexts and experimental results in both oral and written form
Content
- parenteral depot formulations (microparticles, in-situ forming implants)
- nanoparticulate drug formulations for intravenous administration (liposomes, fat emulsions, nanoparticles) incl. drug targeting principles
- formulation principles of oral medicines with improved bioavailability of critical drug compounds (self-emulsifying formulations, solid dispersions and nanocrystals)
- formulation and manufacturing principles of selected above-mentioned drug formulations
- selected analytical methods to characterize the above-mentioned drug formulations (such as microscopy, UV/Vis spectroscopy, particle size analysis, X-ray diffraction, thermal analysis)
Literature
Examination regulations
Exam element a)
Timing
Prerequisites
| Type | Prerequisite name | Prerequisite course |
|---|---|---|
| Examination part | Prerequisites for participating in the exam a) | N570000101, FA808: Advanced drug formulation |
Tests
Report and oral presentation
EKA
Assessment
Grading
Identification
Language
Examination aids
ECTS value
Additional information
Reexamination - Oral examination (30 minutes)
Prerequisites for participating in the exam a)
Timing
Tests
Participation in compulsory examinations and laboratory exercises.
EKA
Assessment
Grading
Identification
Language
Examination aids
ECTS value
Additional information
Indicative number of lessons
Teaching Method
At the faculty of science, teaching is organized after the three-phase model ie. intro, training and study phase.
- intro phase (lectures) - number of hours 4
- training phase - number of hours 42, 24 h seminar and 18 h laboratory
The intro phase consists of lectures providing a short introduction into the central topics of the course.
The training phase provides competences within the central topics of the course. During the seminars, the students will work in small groups on a selected topic (theoretical project) and results of the laboratory exercises will be discussed. I the lab exercises, selected experiments and tests within the central topics of course will be performed.
During the study phase, the students will independently work with the literature to obtain and deepen the central topics of the course. Moreover, the students will recapitulate the tasks from the training phase (writing of reports, work on the theoretical projects) and prepare the final presentation of the theoretical project.
- self-study and after work of topics from the lectures
- literature search and evaluation
- analysis of results from the laboratory exercises
- preparation of a presentation of a selected topic